Medication Guides

Can You Take Ibuprofen with Lisinopril?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.

Yes, you can take ibuprofen with lisinopril, but caution is required due to potential interactions. Taking NSAIDs like ibuprofen with ACE inhibitors like lisinopril can reduce the blood pressure-lowering effects and potentially increase kidney strain. Studies show this combination may increase blood pressure by 5-10 mmHg in some patients. Short-term use of standard ibuprofen doses (400-600mg every 6-8 hours) is generally considered acceptable for most people. However, regular or high-dose ibuprofen use should be avoided. Always consult your healthcare provider before combining these medications, especially if you have kidney problems or take other medications.

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