Can You Take Cialis with Lisinopril?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
Yes, Cialis (tadalafil) can generally be taken with lisinopril safely under medical supervision. These medications work through different mechanisms and don't have significant direct interactions. Lisinopril is an ACE inhibitor that blocks angiotensin-converting enzyme, while Cialis inhibits PDE5 to improve blood flow. However, both medications can lower blood pressure, so combining them may cause additive hypotensive effects in some patients. Studies show that when taken together, the blood pressure reduction is typically mild and well-tolerated. Your doctor may need to monitor your blood pressure more closely when starting this combination, especially during the first few weeks of treatment.
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