Antibiotics & UTI

Can Spermicide Cause a UTI?

Faith Coleman

Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 20th, 2026.

Spermicide does not cause a urinary tract infection (UTI), but can increase your risk of developing UTIs. Nonoxynol-9, the active ingredient in most spermicides, can irritate urogenital tissues and disrupt the natural bacterial balance in the vagina. This disruption may allow bacteria like E. coli to multiply and potentially travel from the vagina to the urethra, causing infection. Studies show that women who use spermicide-containing products have up to a 40% higher risk of UTI, with 2-6 times the rates of UTI, compared to those using other contraceptive methods. The risk is even greater with use of the spermicide more than twice weekly. Diaphragm with spermicide use is also associated with more frequent UTIs. If you experience recurring UTIs while using spermicide, consider discussing alternative contraceptive options with your healthcare provider to reduce infection risk.

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