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Antibiotic Treatment for Sinus Infections
March 31st, 2026

Can Cephalexin Treat a Sinus Infection?

Yes, cephalexin can treat bacterial sinus infections effectively. This first-generation cephalosporin antibiotic works by disrupting bacterial cell wall synthesis, making it effective against common sinus infection bacteria like Streptococcus pneumoniae and Haemophilus influenzae. Typical dosing ranges from 250-500mg every 6-12 hours for 7-10 days, depending on infection severity. However, cephalexin is not effective against viral sinus infections, which account for 90-95% of acute sinusitis cases. Your healthcare provider will determine if your symptoms indicate a bacterial infection requiring antibiotic treatment versus supportive care for viral sinusitis.

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