Can Antidepressants Cause Permanent Sexual Dysfunction?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
Yes, antidepressants can cause permanent sexual dysfunction in some patients, a condition called Post-SSRI Sexual Dysfunction (PSSD). Research suggests 0.5-5% of patients taking SSRIs may experience persistent sexual side effects that continue even after discontinuing the medication. Studies have documented cases where reduced libido, erectile dysfunction, and decreased orgasm intensity lasted months or years after stopping treatment. The FDA added warnings about persistent sexual dysfunction to SSRI labels in 2019. Risk factors include higher doses, longer treatment duration, and individual genetic variations in drug metabolism. If you experience sexual side effects, discuss dosage adjustments or alternative medications with your healthcare provider rather than stopping treatment abruptly.
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