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Zyban (bupropion) is not a nicotine product. It works by blocking the reuptake of dopamine and norepinephrine in the brain, which helps reduce cigarette cravings and lessens the severity of nicotine withdrawal symptoms. You typically start Zyban one to two weeks before your planned quit date so the medication reaches therapeutic levels by the time you stop smoking.

The standard course is 7 to 12 weeks. Some physicians may recommend continuing for up to 6 months in patients who need extended support to prevent relapse. Your physician will recommend the duration that is right for your situation based on your progress and tolerance.

Combining Zyban with nicotine replacement products such as a patch or gum is sometimes done under physician supervision and may improve quit rates for certain patients. However, combining bupropion with nicotine can raise blood pressure, so your physician needs to evaluate whether this combination is appropriate for you.

The most commonly reported side effects include dry mouth, insomnia, headache, dizziness, and nausea. Taking the dose earlier in the day can help reduce sleep problems. Bupropion also carries an FDA warning about the potential for changes in mood, behavior, or thinking in some patients, so it is important to monitor yourself and contact your doctor if you notice unusual changes.

Zyban is not appropriate for people with a seizure disorder, a current or past diagnosis of bulimia or anorexia nervosa, those who have taken an MAO inhibitor within the past 14 days, or patients with a known hypersensitivity to bupropion. People who are already taking Wellbutrin or another bupropion-containing product should not also take Zyban. Your physician will screen for these factors during your evaluation.

Zyban is not associated with weight gain. In clinical studies, bupropion was linked to modest weight loss in some patients. It is worth noting that some people do gain weight after quitting smoking regardless of medication used, largely because of changes in appetite and metabolism that accompany nicotine withdrawal.

Doctronic uses an AI-driven evaluation to gather your health history, symptoms, and goals before connecting you with a licensed physician who reviews your case, makes a clinical determination, and creates a personalized treatment plan. The entire process happens online, so you get expert care without a traditional in-person visit.

Yes. All prescribing on Doctronic is done by fully licensed U.S. physicians. Cases are doctor-reviewed and regularly audited to ensure clinical quality, and the platform is HIPAA-compliant to protect your personal health information. Doctronic is available to adults 18 and older in any U.S. state.