What You Need to Know About Cutaneous Squamous Cell Carcinoma
Published: Apr 14, 2024
Cutaneous Squamous Cell Carcinoma (cSCC) is a type of skin cancer that can look quite different depending on where it appears. This article breaks down its features, diagnosis, and what makes it stand out.
Contents
Recognizing the Signs
cSCC can appear anywhere on the skin but is more common in sun-exposed areas for those with lighter skin. It may show up as a papule, plaque, or nodule that could be smooth, rough, or even ulcerated. For people with darker skin, it often appears in less sun-exposed areas like the lower legs or regions with chronic inflammation.
Diagnosing cSCC
A skin biopsy is necessary to confirm cSCC. This involves removing a small section of the skin to be examined under a microscope. The biopsy helps determine the tumor's characteristics like depth and type, which is crucial for staging the cancer.

Clinical Variants of cSCC
cSCC has various forms, some of which mimic other conditions. Keratoacanthoma grows quickly and looks like a small volcano on the skin. Verrucous carcinoma appears as a wart-like growth in specific areas, while Marjolin ulcers arise in old scars or chronic wounds, often behaving aggressively.
Frequently Asked Questions
cSCC is a type of skin cancer that arises from epidermal cells.
In lighter skin, it often occurs in sun-exposed areas like the face and neck.
Through a skin biopsy that examines the tissue under a microscope.
It can appear as papules, plaques, or nodules on the skin.
Yes, especially in areas like the lips or ears.
Key Takeaways
Understanding cSCC's diverse presentations can be crucial for early detection and treatment.
References
- Waldman A, Schmults C. Cutaneous Squamous Cell Carcinoma. Hematol Oncol Clin North Am 2019; 33:1.
- Gloster HM Jr, Neal K. Skin cancer in skin of color. J Am Acad Dermatol 2006; 55:741.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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