Understanding the Risk Factors for Cutaneous Squamous Cell Carcinoma
Published: Apr 01, 2024
Certain factors can increase the likelihood of developing Cutaneous Squamous Cell Carcinoma (cSCC). This article reveals the top risks associated with this skin cancer.
Contents
Sun Exposure and Skin Type
Prolonged sun exposure is a significant risk factor, particularly for those with fair skin. The UV rays can cause damage to skin cells, increasing the chance of developing cSCC. Those with darker skin may not be as susceptible, but they are not immune.
Genetic Predispositions
Genetics play a role in determining one's risk for cSCC. Individuals with a family history of skin cancer or certain genetic disorders like xeroderma pigmentosum are at a higher risk. These conditions can make the skin more sensitive to UV damage.

Other Contributing Factors
Other factors include a history of sunburns, immunosuppression, and chronic skin conditions. People who have undergone organ transplants or those on certain medications are also at increased risk, as these conditions and treatments can weaken the skin's defenses.
Frequently Asked Questions
Yes, fair skin is more susceptible to UV damage.
Yes, family history and genetic conditions can increase risk.
Yes, repeated sunburns can increase the risk of cSCC.
Yes, due to immunosuppressive medications.
Yes, though it's less common than in fair skin.
Assessing Your Risk
Understanding risk factors can help in early detection and prevention of cSCC.
References
- Hogue L, Harvey VM. Basal Cell Carcinoma, Squamous Cell Carcinoma, and Cutaneous Melanoma in Skin of Color Patients. Dermatol Clin 2019; 37:519.
- Higgins S, Nazemi A, Chow M, Wysong A. Review of Nonmelanoma Skin Cancer in African Americans, Hispanics, and Asians. Dermatol Surg 2018; 44:903.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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