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What Causes Cutaneous Squamous Cell Carcinoma?
Published: Oct 31, 2023
Cutaneous Squamous Cell Carcinoma (cSCC) has various causes, some of which might surprise you. This article dives into the possible reasons behind this skin cancer.
Sun Exposure and Skin Type
For those with lightly pigmented skin, sun exposure is a major cause of cSCC. Repeated exposure to ultraviolet (UV) light can damage skin cells, leading to cancer. People with darker skin tones can also develop cSCC, but it's more common in non-sun-exposed areas and often linked to chronic inflammation or scarring.
HPV and Other Infections
High-risk Human Papillomavirus (HPV) infections are linked to cSCC, especially in the genital and periungual regions. This virus can cause changes in the skin cells, leading to cancer over time. Other infections or treatments like PUVA therapy without proper protection can also contribute.
Chronic Wounds and Scars
Chronic wounds or scars can transform into cSCC, known as Marjolin ulcers. This transformation can take years to occur, but these cancers can be aggressive, with a high risk of spreading if not treated properly.
Frequently Asked Questions
UV light damages skin cells, which can lead to cancer.
Yes, high-risk HPV infections are linked to cSCC.
They are cSCCs that arise from chronic wounds or scars.
It can occur, often in non-sun-exposed areas.
Yes, if done without proper genital protection.
Understanding the Causes
Knowing what causes cSCC can help in preventing it.
References
- Veness MJ. Defining patients with high-risk cutaneous squamous cell carcinoma. Australas J Dermatol 2006; 47:28.
- Eliezri YD, Silverstein SJ, Nuovo GJ. Occurrence of human papillomavirus type 16 DNA in cutaneous squamous and basal cell neoplasms. J Am Acad Dermatol 1990; 23:836.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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