Treating Primary Sclerosing Cholangitis: Current Approaches and Future Possibilities
Published: Mar 13, 2024
Primary sclerosing cholangitis (PSC) is a challenging liver disease to treat. While there's no cure yet, several approaches can help manage symptoms and slow progression.
Contents
Medical Treatments
Ursodeoxycholic acid (UDCA) is often prescribed to improve liver function, though its long-term benefits are debated. Other medications may be used to manage specific symptoms like itching or infections. Immunosuppressants have been studied but haven't shown clear benefits for most patients. Emerging therapies targeting inflammation and fibrosis are under investigation.
Endoscopic Procedures
For patients with dominant strictures (severely narrowed bile ducts), endoscopic procedures can help. Balloon dilation or temporary stent placement can open up blocked ducts, improving bile flow and reducing symptoms. These procedures may need to be repeated periodically as strictures can recur.
Liver Transplantation
For advanced PSC, liver transplantation is the only curative option. Outcomes are generally good, with 5-year survival rates around 85%. However, PSC can recur in the transplanted liver in some cases. Patients need lifelong immunosuppression after transplant.
Frequently Asked Questions
No specific diet is proven, but a healthy, balanced diet is recommended.
Some patients try supplements, but effectiveness is unproven.
Usually every 3-6 months, or more if symptoms worsen.
Moderate exercise is generally safe and may improve overall health.
Key Takeaways
While current treatments for PSC are limited, ongoing research offers hope for more effective therapies in the future.
Discuss with Doctronic which treatment options might be most appropriate for your individual case of PSC.Related Articles
References
Lindor KD, et al. ACG Clinical Guideline: Primary Sclerosing Cholangitis. Am J Gastroenterol. 2015;110(5):646-659.
Karlsen TH, et al. Primary sclerosing cholangitis - a comprehensive review. J Hepatol. 2017;67(6):1298-1323.
Always discuss health information with your healthcare provider.