The Hidden Risks of Factor V Leiden
Published: Mar 07, 2024
Factor V Leiden is a genetic mutation that can increase your risk of certain blood clots. Knowing your risk factors is crucial for prevention.
Contents
How Factor V Leiden Increases Risk
Factor V Leiden alters a blood protein, making it resistant to a key anticoagulant action. This leads to an increased risk of venous thromboembolism (VTE). However, not everyone with the mutation will experience clotting issues.
Genetic and Environmental Influences
The risk of clotting increases if you inherit the mutation from both parents or have other genetic disorders. External factors like age, pregnancy, or contraceptive use can also spike the risk. Understanding these can help manage and mitigate potential health issues.

Common Misconceptions
One common misconception is that everyone with Factor V Leiden will have blood clots. In reality, many never experience symptoms. Lifestyle choices and other health conditions can play significant roles in whether complications develop.
Frequently Asked Questions
It affects a protein involved in blood clotting.
No, many live symptom-free.
Genetics, age, pregnancy, and hormone use.
Yes, understanding your risks can guide preventive measures.
The Bottom Line
Factor V Leiden presents risks, but being informed helps manage them effectively.
References
- Juul K, Tybjaerg-Hansen A, Schnohr P, et al. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med 2004; 140:330.
- Simioni P, Prandoni P, Lensing AW, et al. The risk of recurrent venous thromboembolism in patients with an Arg506-->Gln mutation in the gene for factor V (factor V Leiden). N Engl J Med 1997; 336:399.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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