Contents
Is Factor V Leiden Putting You at Risk?
Published: Aug 18, 2024
Factor V Leiden is a genetic mutation that increases your risk of blood clots. Understanding this condition can help manage and reduce potential health risks.
Understanding Factor V Leiden
Factor V Leiden is a mutation in the F5 gene, affecting a protein crucial for blood clotting. This mutation makes the protein resistant to regulation by activated protein C (aPC), a natural anticoagulant. As a result, individuals with this mutation have a higher risk of developing venous thromboembolism (VTE), though many never experience symptoms.
The Risk Factors and Genetics
While Factor V Leiden is the most common inherited thrombophilia in white populations, only a small percentage will develop VTE. The risk increases with other genetic factors like homozygosity or additional mutations. Environmental factors, such as age and hormonal changes, can also heighten the risk.
Diagnosis and Testing
Diagnosis of Factor V Leiden involves genetic testing or functional assays for aPC resistance. Genetic testing is more definitive, especially for those with a family history of thrombophilia. Functional assays can be affected by other medications, making genetic testing preferable in some cases.
Frequently Asked Questions
It's a genetic mutation that affects blood clotting and increases clot risk.
It's the most common inherited thrombophilia in white populations.
No, many people with the mutation never develop clots.
Genetic tests and functional assays for aPC resistance.
Yes, age and hormonal changes can increase risk.
Key Takeaways
Factor V Leiden is a common mutation, but understanding your genetic risk can help manage potential health impacts.
References
- Ridker PM, Hennekens CH, Lindpaintner K, et al. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in healthy men. N Engl J Med 1995; 332:912.
- Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369:64.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
AI Doctor Visit Required
Appointments available 24/7
Top licensed doctors
Available in all 50 states
Full service care
Prescriptions, referrals & treatment
No insurance needed
All notes available in Doctronic
15-min consultation. No hidden costs.
AI Doctor Visit Required
Please Chat With Our AI Doctor First
Our AI doctor assessment helps our human doctors prepare for your video visit and provide better care
For safety reasons we have been forced to end this consultation.
If you believe this is a medical emergency please call 911 or your local emergency services immediately.
If you are experiencing emotional distress, please call the the Suicide & Crisis Lifeline at 988 or your local crisis services immediately.
Contact us
You can also email us at help@doctronic.ai
We aim to reply within 5-7 days
How likely are you to recommend Doctronic to friends or family?