Testing for Factor V Leiden: What You Need to Know
Published: Dec 21, 2023
Factor V Leiden testing can predict your risk of blood clots. Knowing the right test can lead to better health management.
Contents
Understanding the Tests
Factor V Leiden can be diagnosed through genetic testing or functional assays. Genetic testing analyzes your DNA for the mutation, offering a definitive result. Functional assays test how your blood responds to activated protein C, indicating potential resistance.
When to Consider Testing
Testing is often recommended for those with a family history of thrombophilia or personal history of unusual blood clots. Pregnant women or those planning to use hormonal contraceptives might also consider testing to manage potential risks.

Interpreting Your Results
A positive test doesn't mean you'll definitely have health issues. It's important to discuss results with a healthcare provider, who can help interpret them in the context of your overall health and family history.
Frequently Asked Questions
Genetic tests and functional assays.
Those with family history or unusual blood clots.
It indicates a mutation, but not definite health issues.
Genetic tests are more definitive.
Wrapping Up
Testing for Factor V Leiden can guide health decisions and risk management.
References
- Kadauke S, Khor B, Van Cott EM. Activated protein C resistance testing for factor V Leiden. Am J Hematol 2014; 89:1147.
- PrΓΌller F, Weiss EC, Raggam RB, et al. Activated protein C resistance assay and factor V Leiden. N Engl J Med 2014; 371:685.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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