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Risk Factors for Scleroderma: Who's Most at Risk?
Published: Jun 02, 2024
Identifying who is most at risk for developing scleroderma can help in early detection and management of the condition.
Gender and Age
Scleroderma predominantly affects women, with the onset of symptoms typically occurring between the ages of 30 and 50. This gender disparity suggests that hormonal factors may play a role in the disease's development. Understanding these demographics can assist in early screening and intervention strategies.
Genetic Predisposition
While scleroderma is not directly hereditary, certain genetic markers are linked to an increased risk. Family history of autoimmune diseases can also elevate risk. Genetic predisposition plays a subtle role but is significant enough to warrant attention in family medical histories.
Environmental Triggers
Exposure to certain chemicals or infections might trigger scleroderma in susceptible individuals. Occupational hazards, such as working with silica dust or solvents, have been associated with increased risk. Limiting exposure to these environmental factors can be a preventive measure for those at risk.
Frequently Asked Questions
Women aged 30-50 are most affected.
No, but genetic markers can increase risk.
Exposure to chemicals like silica dust may increase risk.
Yes, a family history of autoimmune diseases can elevate risk.
Yes, jobs involving solvents and dust may pose risks.
Key Takeaways
Understanding these risk factors can aid in early detection and preventative care for scleroderma.
References
- Nihtyanova SI, Sari A, Harvey JC, et al. Using Autoantibodies and Cutaneous Subset to Develop Outcome-Based Disease Classification in Systemic Sclerosis. Arthritis Rheumatol 2020; 72:465.
- Denton CP, Hughes M, Gak N, et al. BSR and BHPR guideline for the treatment of systemic sclerosis. Rheumatology (Oxford) 2016; 55:1906.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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