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Can We Treat Scleroderma? Exploring the Latest Treatment Options
Published: May 05, 2024
Treating scleroderma is challenging due to its complex nature and varying symptoms. This article explores the latest treatment options and strategies.
Initial Treatment Strategies
For patients with progressive and diffuse skin involvement, treatments like methotrexate (MTX) or mycophenolate mofetil (MMF) are commonly used. These medications are often initiated early to slow disease progression. The choice between MTX and MMF depends on other symptoms present, such as arthritis or lung involvement, as neither shows clear superiority.
Advanced and Resistant Cases
For scleroderma cases resistant to initial treatments, intravenous immunoglobulin (IVIG), rituximab, or tocilizumab may be considered. These treatments are reserved for severe cases due to their potential side effects. Cyclophosphamide is also an option for rapidly progressing skin thickening but is typically reserved for severe cases.
Managing Other Symptoms
Patients often experience symptoms like pruritus, which can be managed with topical treatments and antihistamines. For severe itching, short courses of low-dose glucocorticoids may be used cautiously due to potential renal risks. Other skin manifestations, such as calcinosis cutis, may require treatments like minocycline or even surgery.
Frequently Asked Questions
Methotrexate or mycophenolate mofetil is often used first.
IVIG, rituximab, or tocilizumab may be considered.
Topical treatments and antihistamines are used.
Yes, especially for calcinosis cutis if other treatments fail.
They can increase the risk of renal crisis in scleroderma.
Wrapping Up
While no cure exists, several treatment options can effectively manage scleroderma symptoms.
References
- Nihtyanova SI, Sari A, Harvey JC, et al. Using Autoantibodies and Cutaneous Subset to Develop Outcome-Based Disease Classification in Systemic Sclerosis. Arthritis Rheumatol 2020; 72:465.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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