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Memantine: A New Hope for Advanced Alzheimer's?
Published: Aug 14, 2024
Dive into the benefits of memantine for advanced Alzheimer's disease and how it may offer a new approach to treatment.
Understanding Memantine
Memantine works as an NMDA receptor antagonist, helping to regulate glutamate activity in the brain. This is important because excessive glutamate can lead to brain cell damage. Memantine is thought to protect brain cells and improve symptoms in moderate to severe Alzheimer's cases.
Combining Treatments
Memantine is often used in combination with cholinesterase inhibitors for improved results. Studies show that this combination can lead to modest improvements in cognition and daily activities, especially in those with advanced Alzheimer's. However, it's important to consider patient-specific factors like drug tolerability and cost.
Memantine's Side Effects
Memantine is generally well-tolerated, with dizziness being the most common side effect. Unlike some other treatments, it doesn't significantly increase the risk of confusion or hallucinations. This makes it a viable option for many patients with advanced Alzheimer's.
Frequently Asked Questions
It's used to treat moderate to severe Alzheimer's symptoms.
It regulates glutamate activity to protect brain cells.
Yes, it's often used with cholinesterase inhibitors for better outcomes.
Dizziness is the most common side effect, but it's generally well-tolerated.
The Bottom Line
Memantine offers hope for those with advanced Alzheimer's, but personalized treatment is key.
References
- Raina P, Santaguida P, Ismaila A, et al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 2008; 148:379.
- Chen R, Chan PT, Chu H, et al. Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. PLoS One 2017; 12:e0183586.
- Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 2004; 291:317.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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