Is It Just Diarrhea or Something More? Recognizing CDI Symptoms
Published: Apr 21, 2024
Diarrhea is common, but when it's linked to C. difficile infection (CDI), it can be severe. Knowing the symptoms can help you take action early.
Contents
Common Symptoms: The Usual Suspects
The hallmark of CDI is watery diarrhea, occurring three or more times in 24 hours. Other symptoms can include lower abdominal pain, cramping, and fever. In nonsevere cases, these symptoms may be mild but should not be ignored, especially if antibiotics are involved.
When Things Get Serious
Severe CDI can lead to serious conditions like toxic megacolon, which is characterized by a swollen colon and severe abdominal pain. Patients may also experience dehydration, high fever, and elevated white blood cell counts. In extreme cases, CDI can lead to life-threatening complications.

Recurrence: When Symptoms Return
Even after successful treatment, CDI symptoms can return, typically within two to eight weeks. Recurrent CDI is common, affecting up to 25% of patients. Risk factors for recurrence include older age and ongoing antibiotic use.
Frequently Asked Questions
CDI symptoms include watery diarrhea and abdominal pain.
Yes, severe CDI can lead to life-threatening conditions.
Yes, CDI can recur within two to eight weeks after treatment.
Wrapping Up
Recognizing CDI symptoms early can prevent severe outcomes.
References
- Kelly CR, et al. ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections. Am J Gastroenterol 2021; 116:1124.
- Tedesco FJ. Pseudomembranous colitis: pathogenesis and therapy. Med Clin North Am 1982; 66:655.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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