Contents
Exploring Therapy Options for von Willebrand Disease: What's the Best Fit for You?
Published: Oct 21, 2023
Choosing the right therapy for von Willebrand disease can make a big difference in managing symptoms and improving quality of life.
DDAVP and VWF Concentrates
DDAVP is typically effective for minor bleeding, especially in Type 1 VWD patients. For those who do not respond to DDAVP, VWF concentrates are the next option. VWF concentrates can stabilize factor VIII and are useful in more severe cases or prolonged bleeding.
Antifibrinolytic Agents
Antifibrinolytic agents like tranexamic acid help stabilize blood clots and are particularly effective for mucosal bleeds. These agents can be used alone or in conjunction with other therapies, depending on the severity and location of the bleeding.
Topical Treatments and Estrogens
Topical agents like thrombin can be applied directly to bleeding areas, providing quick relief. Estrogens, often in the form of oral contraceptives, can be used to manage heavy menstrual bleeding in women with VWD.
Frequently Asked Questions
DDAVP increases VWF levels to manage minor bleeding.
They are used when DDAVP is ineffective or for severe cases.
They stabilize clots and are effective for mucosal bleeds.
The Bottom Line
Choosing the right therapy is crucial for effective management of von Willebrand disease.
References
- Federici AB, Mazurier C, Berntorp E, et al. Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study. Blood 2004; 103:2032.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
AI Doctor Visit Required
Appointments available 24/7
Top licensed doctors
Available in all 50 states
Full service care
Prescriptions, referrals & treatment
No insurance needed
All notes available in Doctronic
15-min consultation. No hidden costs.
AI Doctor Visit Required
Please Chat With Our AI Doctor First
Our AI doctor assessment helps our human doctors prepare for your video visit and provide better care
For safety reasons we have been forced to end this consultation.
If you believe this is a medical emergency please call 911 or your local emergency services immediately.
If you are experiencing emotional distress, please call the the Suicide & Crisis Lifeline at 988 or your local crisis services immediately.
Contact us
You can also email us at help@doctronic.ai
We aim to reply within 5-7 days
How likely are you to recommend Doctronic to friends or family?