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DDAVP: The Go-To Treatment for von Willebrand Disease
Published: Jun 22, 2024
DDAVP (desmopressin) is a key treatment for managing von Willebrand disease, especially in minor bleeding situations.
What is DDAVP?
DDAVP is a synthetic hormone that helps increase levels of von Willebrand factor in the blood, aiding in clot formation. It's especially useful for patients with Type 1 VWD and some with Type 2. The drug is administered either intravenously, subcutaneously, or intranasally.
When to Use DDAVP
DDAVP is best used for minor bleeds and minor surgeries in patients who have shown a positive response during a DDAVP trial. It should not be used in children under 2, in Type 3 VWD patients, or those with cardiovascular conditions due to potential side effects.
Potential Side Effects
While generally safe, DDAVP can cause side effects like hyponatremia, flushing, and headaches. Fluid intake should be restricted to reduce the risk of hyponatremia. Always consult with a healthcare provider for personalized advice.
Frequently Asked Questions
DDAVP is used to treat minor bleeding in von Willebrand disease.
Children under 2 and individuals with Type 3 VWD should avoid it.
Side effects include hyponatremia, flushing, and headaches.
The Bottom Line
DDAVP is a valuable treatment tool, but it requires careful administration and monitoring.
References
- Federici AB, Mazurier C, Berntorp E, et al. Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study. Blood 2004; 103:2032.
- Rodeghiero F, Castaman G, Mannucci PM. Prospective multicenter study on subcutaneous concentrated desmopressin for home treatment of patients with von Willebrand disease and mild or moderate hemophilia A. Thromb Haemost 1996; 76:692.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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