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Beyond Levodopa: Alternative Treatments for Parkinson's Disease
Published: Oct 31, 2023
While levodopa is the primary treatment for Parkinson's disease, other medications can also help manage symptoms. These alternatives may be used alone or in combination with levodopa.
Dopamine Agonists: Mimicking Dopamine
Dopamine agonists trick the brain into thinking it's receiving dopamine. They can be used early in the disease or later to complement levodopa. Common options include pramipexole, ropinirole, and rotigotine patches. While generally less potent than levodopa, they may have a lower risk of causing dyskinesias.
MAO-B Inhibitors: Preserving Dopamine
These medications, such as selegiline and rasagiline, work by blocking an enzyme that breaks down dopamine in the brain. This helps preserve the brain's natural dopamine and can enhance the effects of levodopa. They're often used in early Parkinson's or as an add-on therapy.
Amantadine: Multi-Purpose Helper
Amantadine has a unique role in Parkinson's treatment. It can be used early in the disease to help with symptoms, particularly tremor. Later on, it's often used to help manage dyskinesias caused by long-term levodopa use. Its exact mechanism isn't fully understood, but it appears to affect multiple brain systems.
Frequently Asked Questions
They may delay the need for levodopa but rarely replace it entirely.
Each has its own side effect profile; discuss with your doctor.
Your doctor will consider your symptoms, age, and other factors.
Tailored Treatment
With various options available, Parkinson's treatment can be personalized to each individual's needs and response.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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