Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 22nd, 2026.
Winlevi is a unique topical acne treatment targeting androgen receptors
Most side effects are mild and localized to the skin
Proper application and moisturizing can minimize adverse reactions
Consult a healthcare provider for persistent or severe symptoms
Winlevi (clascoterone) represents an innovative approach to treating acne by targeting androgen receptors directly on the skin. As the first FDA-approved topical medication of its kind, it offers hope for patients struggling with persistent acne. However, like all medications, understanding its potential side effects is crucial for safe and effective use.
Patients using Winlevi may experience several localized side effects. Skin redness, or benzoyl peroxide interactions, can occur at the application site, typically during the initial weeks of treatment. This erythema is usually mild and subsides as the skin adapts to the medication.
Dryness and scaling are also common reactions. Some patients notice their skin becoming slightly flaky or rough, particularly in the first few weeks of treatment. Side effects of benzoyl peroxide share similar skin reaction patterns, providing a familiar reference point for those experienced with acne treatments.
Itching and mild irritation represent typical responses to Winlevi application. Patients might experience a tingling sensation or slight burning, which usually diminishes with continued use. These sensations are generally mild and do not require treatment discontinuation.
To minimize irritation, adapalene interactions suggest similar management strategies. Patients can:
Use a gentle, fragrance-free moisturizer
Apply sunscreen daily
Start with less frequent applications
Avoid other potentially irritating skincare products
While rare, some serious side effects require immediate medical attention. Allergic reactions may manifest as:
Widespread rash
Hives
Facial or throat swelling
Difficulty breathing
Severe local reactions might include:
Intense burning
Blistering
Skin ulceration
Signs of infection (increased redness, warmth, swelling)
Patients should be cautious about combining Winlevi with other treatments. Generic vs. brand-name drugs guidance suggests consulting healthcare providers about potential interactions.
Potential Interactions |
Recommendation |
|---|---|
Retinoids |
Avoid concurrent use |
Benzoyl Peroxide |
Use with caution |
Other Topical Acne Treatments |
Consult healthcare provider |
Hormonal Medications |
Discuss potential systemic effects |
Proper application technique can significantly reduce adverse reactions. Healthcare providers recommend:
Starting with once-daily application
Gradually increasing to twice-daily use
Using a gentle moisturizer
Protecting skin from sun exposure
Most side effects are mild and subside within 2-4 weeks of starting treatment.
Wait at least 15-20 minutes after application before applying makeup.
The medication is approved for patients 12 years and older.
Discontinue use and consult your healthcare provider immediately.
While rare, some patients may experience mild hormonal side effects.
Winlevi offers an innovative approach to acne treatment with a manageable side effect profile. Most patients tolerate the medication well when used as directed. Care you can trust. Doctronic is clinically validated with 99% treatment plan alignment.
Winlevi (clascoterone) represents an innovative approach to treating acne by targeting androgen receptors directly on the skin. As the first FDA-approved topical medication [...]
Read More
