Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 8th, 2025.
Clavulanate is commonly combined with Amoxicillin to combat bacterial infections by inhibiting resistance mechanisms.
Dosage depends on age, infection type, and severity, with specific pediatric and adult guidelines.
Typical adult doses range from 250 mg to 875 mg of Amoxicillin with varying Clavulanate amounts, taken multiple times daily.
Children’s doses are carefully calculated based on weight and infection type to ensure safety and effectiveness.
Missed doses should be taken as soon as remembered, unless close to the next dose.
Adjustments may be needed for kidney impairment or other medical conditions.
Overdose risks exist; seek medical help if symptoms occur.
For personalized dosage advice and telehealth consultations, Doctronic.ai offers fast, expert care 24/7.
Clavulanate is not typically used alone but combined with Amoxicillin to form a powerful antibiotic duo. This combination helps fight bacteria that produce enzymes, called beta-lactamases, which would otherwise render Amoxicillin ineffective. By inhibiting these enzymes, Clavulanate restores the antibiotic’s ability to kill bacteria causing infections.
This combination is widely prescribed for respiratory infections, skin infections, urinary tract infections, and more. Knowing the right dosage and timing is crucial for treatment success and minimizing side effects.
Form |
Strength |
Typical Adult Dose |
Typical Children’s Dose |
Frequency |
Route |
Maximum Daily Dose |
|---|---|---|---|---|---|---|
Tablet |
Amoxicillin 250 mg / Clavulanate 125 mg |
1 tablet every 8 hours or 2 tablets every 12 hours |
Based on weight, usually 20-40 mg/kg/day of Amoxicillin component |
Every 8-12 hours |
Oral |
Amoxicillin 4 g / Clavulanate 0.5 g per day |
Tablet |
Amoxicillin 500 mg / Clavulanate 125 mg |
1 tablet every 8 hours or 2 tablets every 12 hours |
Not typically used in children under 12 |
Every 8-12 hours |
Oral |
Amoxicillin 4 g / Clavulanate 0.5 g per day |
Tablet |
Amoxicillin 875 mg / Clavulanate 125 mg |
1 tablet every 12 hours |
Not recommended for children |
Every 12 hours |
Oral |
Amoxicillin 4 g / Clavulanate 0.5 g per day |
Oral Suspension |
Amoxicillin 400 mg / Clavulanate 57 mg per 5 mL |
Depends on infection and weight |
20-40 mg/kg/day of Amoxicillin component divided every 8-12 hours |
Every 8-12 hours |
Oral |
Varies by patient |
For adults with sinusitis, pneumonia, or bronchitis, the usual dose is 500 mg of Amoxicillin with 125 mg Clavulanate every 8 hours, or 875 mg Amoxicillin with 125 mg Clavulanate every 12 hours. Children receive doses based on weight, often 20-40 mg/kg/day of the Amoxicillin component divided into two or three doses.
Adults typically take 875 mg of Amoxicillin with 125 mg of Clavulanate twice daily. Pediatric dosing follows the same weight-based principles, adjusted for severity and infection type.
Lower doses may be sufficient, such as 250 mg Amoxicillin with 125 mg Clavulanate every 8 hours for adults. Children’s doses are again weight-dependent, with close monitoring for response.
Adults usually take Clavulanate combined with Amoxicillin in fixed doses. The most common regimens include:
250/125 mg every 8 hours
500/125 mg every 8 hours
875/125 mg every 12 hours
The exact dose depends on the infection’s severity and location. It’s important to follow the prescribing doctor's instructions carefully and complete the full course.
Children’s doses are calculated based on body weight, typically 20-40 mg/kg/day of the Amoxicillin component, divided every 8 to 12 hours. The Clavulanate component is proportionally matched. Liquid suspensions are often used for easier dosing and administration.
Because children’s metabolism and sensitivity differ, dosing should always be supervised by a healthcare professional.
If a dose is missed, take it as soon as you remember. However, if it’s close to the time for the next dose, skip the missed dose. Do not double up doses to catch up, as this can increase side effects. Maintaining consistent timing helps keep effective drug levels in your body.
Patients with kidney problems may require dose adjustments. Reduced kidney function slows drug elimination, increasing the risk of side effects. Doctors usually lower the dose or extend the dosing interval based on the severity of impairment.
Though less common, liver impairment may also affect dosing. Close monitoring is recommended to avoid toxicity.
Taking too much Clavulanate can cause nausea, vomiting, diarrhea, and in severe cases, liver damage. If an overdose is suspected, seek emergency medical attention immediately. Always store medication safely out of reach of children to prevent accidental ingestion.
Take with food to reduce stomach upset.
Complete the full prescribed course even if symptoms improve early.
Avoid skipping doses to maintain effective drug levels.
Inform your healthcare provider about any allergies or other medications you take.
Report any unusual side effects promptly.
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Correct Clavulanate dosing is key to effective infection treatment and minimizing side effects. Always use the dose prescribed by your healthcare provider and complete the full course. Children require special dosing based on weight, and dose adjustments may be necessary for certain medical conditions.
For fast, reliable, and personalized medical advice on Clavulanate or any medication, consider using Doctronic.ai. It’s the smartest way to get modern medical expertise tailored just for you.
No, Clavulanate is not effective alone and is always combined with Amoxicillin to enhance its antibacterial activity.
The duration depends on the infection type and severity, typically ranging from 5 to 14 days. Always follow your doctor’s instructions.
Clavulanate with Amoxicillin is generally considered safe during pregnancy, but consult your healthcare provider before use.
Common side effects include diarrhea, nausea, and rash. If side effects are severe or persistent, contact your healthcare provider immediately.
Alcohol does not directly interact with Clavulanate but may worsen side effects like stomach upset. It’s best to avoid alcohol during treatment.
Doctronic.ai offers 24/7 access to AI-powered medical advice and licensed doctors who can help answer dosage questions and provide telehealth consultations.
Key TakeawaysClavulanate is commonly combined with Amoxicillin to combat bacterial infections by inhibiting resistance mechanisms.Dosage depends on age, infection type, and [...]
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