7 Common and Serious Side Effects of Symbicort

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 18th, 2025.

Key Takeaways

  • Symbicort is a combination inhaler used to manage asthma and COPD symptoms.

  • Common side effects include throat irritation, sinusitis, thrush, headache, and hoarseness.

  • Serious side effects like increased heart rate, pneumonia risk, and adrenal insufficiency require prompt medical attention.

  • Side effects can often be managed with proper inhaler technique and lifestyle adjustments.

  • Doctronic.ai offers personalized telehealth visits to help understand and manage Symbicort side effects effectively.

Understanding Symbicort Side Effects

Symbicort is a combination inhaler containing Budesonide, a corticosteroid that reduces airway inflammation, and formoterol, a long-acting bronchodilator that relaxes the muscles around the airways. This dual-action formula makes Symbicort an effective treatment option for individuals with asthma or chronic obstructive pulmonary disease (COPD). By decreasing swelling and improving airflow, Symbicort helps relieve symptoms such as wheezing, coughing, and shortness of breath, while also reducing the risk of severe flare-ups.

To get the full benefit of Symbicort, consistent use is essential. Taking the medication exactly as prescribed can significantly improve lung function and overall quality of life. Proper inhaler technique also matters; using a spacer or practicing slow, controlled breathing can enhance medication delivery and reduce throat irritation or hoarseness. Patients should rinse their mouth after each dose to minimize the risk of oral thrush, a common side effect of inhaled corticosteroids.

Symbicort may cause side effects, ranging from mild irritation to more serious reactions. Monitoring symptoms and maintaining open communication with a healthcare provider ensures that any issues are addressed promptly. Doctronic.ai offers accessible support, helping patients navigate side effects, optimize treatment, and feel confident in managing their respiratory health.

1. Throat Irritation and Hoarseness

One of the most common side effects of Symbicort is throat irritation. This can feel like a scratchy or sore throat and may be accompanied by hoarseness or a change in voice. These symptoms occur because the inhaled corticosteroid Budesonide can affect the mucous membranes in the throat.

Using a spacer device with the inhaler or rinsing the mouth after use can reduce irritation. If hoarseness persists or worsens, it might indicate a fungal infection called oral thrush, which requires medical treatment.

2. Headache

Some Symbicort users report headaches. These can range from mild tension headaches to more severe migraines. The exact cause is unclear, but it may relate to the medication’s effects on blood vessels or immune response.

Staying hydrated, managing stress, and using over-the-counter pain relievers can help. If headaches become frequent or severe, consult a healthcare provider for evaluation.

3. Increased Heart Rate and Palpitations

Formoterol, the long-acting bronchodilator in Symbicort, can cause an increased heart rate or palpitations. This side effect is usually mild but can be uncomfortable or concerning, especially for people with pre-existing heart conditions.

If you notice a rapid or irregular heartbeat after using Symbicort, it’s important to discuss this with your doctor. Sometimes adjusting the dose or switching medications is necessary.

4. Muscle Cramps and Tremors

Some users experience muscle cramps or tremors, likely due to the stimulant effect of formoterol on muscle tissue. These symptoms are usually mild and temporary, but can affect daily activities if persistent.

Stretching exercises and proper hydration may reduce muscle discomfort. Persistent symptoms should be reported to a healthcare provider.

5. Pneumonia Risk in COPD Patients

Research shows that inhaled corticosteroids like Budesonide may increase the risk of pneumonia in people with COPD. This is a serious side effect that requires immediate medical attention if symptoms such as fever, increased cough, or chest pain develop.

Patients should monitor respiratory symptoms closely and maintain regular check-ups with their healthcare provider.

6. Adrenal Insufficiency

Long-term use of corticosteroids can suppress the body’s natural adrenal function, leading to adrenal insufficiency. Symptoms include fatigue, weakness, nausea, and dizziness. This condition can be serious and requires medical management.

Doctors usually monitor for this side effect during extended treatment periods and may adjust medication accordingly.

7. Allergic Reactions

Though rare, some people may have allergic reactions to Symbicort. Signs include rash, itching, swelling, severe dizziness, or difficulty breathing. These require immediate emergency care.

Man using a blue asthma inhaler outdoorsHow to Manage and Reduce Side Effects of Symbicort

Proper Inhaler Technique

Using Symbicort correctly is the best way to minimize side effects. This includes shaking the inhaler before use, breathing out fully before inhaling, and holding your breath for about 10 seconds after inhalation. Using a spacer can also help deliver medication more effectively and reduce throat irritation.

Rinsing Your Mouth After Use

Rinsing and gargling with water after each dose helps prevent oral thrush and reduces irritation. Avoid swallowing the rinse water to remove any residual corticosteroid from the mouth.

Monitoring Symptoms

Keep a symptom diary to track any side effects and their severity. This information can be vital during telehealth visits or doctor appointments to adjust treatment plans.

Healthy Lifestyle Choices

Maintaining hydration, managing stress, and avoiding smoking or other lung irritants support overall respiratory health and reduce side effect risks.

Symbicort Allergic Reactions and Warnings

Allergic reactions to Symbicort are uncommon but serious. If you experience swelling of the face, lips, tongue, or throat, or have difficulty breathing, seek emergency medical help immediately. Always inform your healthcare provider about any allergies or previous reactions to medications before starting Symbicort.

When to Contact Your Doctor About Symbicort Side Effects

Contact your healthcare provider if you experience:

  • Persistent or worsening throat irritation or hoarseness

  • Frequent or severe headaches

  • Rapid or irregular heartbeat

  • Signs of infection, such as fever, chills, or increased cough

  • Muscle weakness or severe cramps

  • Symptoms of adrenal insufficiency, such as fatigue or dizziness

  • Any signs of allergic reaction

Early communication can prevent complications and ensure your treatment remains safe and effective.

Learn More About Symbicort Side Effects With Doctronic

Managing medication side effects can be challenging, but you don’t have to do it alone. Doctronic.ai offers personalized telehealth visits with licensed doctors available 24/7 across all 50 states. Whether you have questions about Symbicort side effects or need advice on managing symptoms, Doctronic’s AI-powered platform provides fast, comprehensive answers tailored to your health history.

Visit Doctronic.ai to get started with a free AI doctor visit or schedule an affordable video consultation. With over 10 million users, Doctronic is revolutionizing how patients access modern, personalized care.

The Bottom Line About Symbicort Side Effects

Symbicort is an effective medication for asthma and COPD, but it comes with a range of possible side effects. Most are mild and manageable with proper technique and care. Serious side effects, while less common, require prompt attention. Staying informed and maintaining open communication with healthcare providers is key.

Telehealth services like Doctronic.ai make it easier than ever to get expert guidance without leaving home. Personalized care powered by AI can help you navigate your treatment safely and confidently.

Frequently Asked Questions

Weight gain is not a common side effect of Symbicort. Corticosteroids can sometimes affect metabolism if used in high doses over a long time. Discuss any concerns with your doctor.

Symbicort should only be used during pregnancy if clearly needed. Consult your healthcare provider to weigh the benefits and risks.

If you miss a dose, take it as soon as you remember. If it’s close to the next dose, skip the missed one. Do not double the dose.

Do not stop Symbicort abruptly without consulting your doctor, as this can worsen your respiratory condition.

Doctronic.ai offers AI-powered personalized advice and telehealth visits with doctors who can help you understand side effects and adjust your treatment safely.

References

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