When Should You Take Naltrexone?

Naltrexone timing depends on the specific formulation and condition being treated. For alcohol use disorder, oral naltrexone (50mg) is typically taken once daily, preferably in the morning to minimize sleep disruption. The extended-release injection (Vivitrol) is administered monthly by a healthcare provider. For opioid use disorder, treatment should begin only after 7-10 days of complete opioid abstinence to prevent precipitated withdrawal. Some patients experience nausea or fatigue, so taking it with food or at bedtime may help. Your doctor will determine the optimal timing based on your medical history, current medications, and treatment goals.