What is the Cheapest Antibiotic for a UTI?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
The most affordable UTI antibiotics are typically generic versions of commonly prescribed medications. Trimethoprim-sulfamethoxazole (generic Bactrim) costs $4-10 for a 3-day course, while nitrofurantoin (generic Macrobid) ranges from $10-15 for a 5-day treatment. Fosfomycin (generic Monurol) offers a single-dose option at $15-25. Generic antibiotics are 80-90% less expensive than brand-name versions. The specific antibiotic prescribed depends on factors including bacterial resistance patterns in your area, medical history, and any drug allergies. A healthcare provider must evaluate your symptoms to determine the most appropriate and cost-effective treatment option.
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