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Understanding Serious Medication Risks
February 19th, 2026

What Are the Worst Side Effects of Wegovy

Wegovy's most serious side effects include severe gastrointestinal complications, pancreatitis, and potential thyroid tumors. Gastroparesis, a condition causing delayed stomach emptying, affects up to 5% of patients and can lead to persistent nausea, vomiting, and malnutrition. Acute pancreatitis occurs in approximately 0.2% of users, presenting with severe abdominal pain radiating to the back. Clinical trials revealed thyroid C-cell tumors in animal studies, though human risk remains unclear. Additional severe reactions include gallbladder disease, kidney problems from dehydration, and suicidal thoughts in some patients. Most concerning symptoms warrant immediate medical attention, especially persistent vomiting, severe abdominal pain, or changes in vision.

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