Doctronic.ai > Questions > Does the Depo Shot Make You Gain Weight?
Understanding Depo Shot Side Effects
March 31st, 2026

Does the Depo Shot Make You Gain Weight?

Yes, the Depo shot can cause weight gain, though not everyone experiences this side effect. Clinical studies show that women gain an average of 5.4 pounds during the first year of use, with some gaining up to 11 pounds over two years. The weight gain typically results from increased appetite and fluid retention caused by the synthetic hormone medroxyprogesterone acetate. About 25% of users experience significant weight gain, while others maintain stable weight. Weight gain tends to be more pronounced in younger women and those who were already overweight before starting the injection. If you're concerned about weight changes, discuss alternative contraceptive options with your healthcare provider.

Related Questions

Related Articles

Complete Guide to Depo Provera Side Effects

This comprehensive guide covers all potential side effects of the Depo shot, including weight changes, bone density loss, and irregular bleeding. Learn what to expect and when to contact your doctor.

Birth Control Methods That Don't Affect Weight

Explore contraceptive options with minimal impact on weight, including IUDs, barrier methods, and newer hormonal formulations. Compare effectiveness rates and side effect profiles.

Managing Weight While on Hormonal Birth Control

Practical strategies for maintaining a healthy weight while using hormonal contraceptives, including diet tips, exercise recommendations, and when to consider switching methods.

Learn More

More from Doctronic