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Birth Control & Women's Health

Does the Depo Shot Make You Gain Weight?

Andre Stone | MD

Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.

Yes, the Depo shot can cause weight gain, though not everyone experiences this side effect. Clinical studies have found an average weight gain of about 5 pounds during the first year, although individual changes vary and weight may continue to increase with longer use. Researchers do not fully understand why some people gain weight while using medroxyprogesterone acetate; changes in appetite, body fat, and metabolism may play a role. Some users gain a substantial amount of weight, while others gain little or no weight. The likelihood depends partly on how “significant” weight gain is defined and how long the shot is used. Younger users may be more likely to gain weight, but starting weight alone does not reliably predict who will be affected. Gaining more than 5% of your starting weight during the first six months may signal a higher chance of continued weight gain. If you're concerned about weight changes, discuss alternative contraceptive options with your healthcare provider.

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