Does Birth Control Affect Your Mood or Cause Depression?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
Yes, hormonal birth control can affect mood and may increase depression risk in some women. Studies show that hormonal contraceptives containing synthetic estrogen and progestin can alter neurotransmitter levels, particularly serotonin and GABA, which regulate mood. Research indicates women using hormonal birth control have a 23% higher risk of depression diagnosis compared to non-users. The progestin component appears most problematic, with newer synthetic versions like drospirenone showing stronger mood effects. Risk factors include personal or family history of depression, age under 20, and sensitivity to hormonal changes. Non-hormonal options like copper IUDs don't carry these mood risks.
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