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Birth Control & Women's Health

Does Amoxicillin Cancel Out Birth Control?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.

No, amoxicillin does not cancel out birth control pills in most cases. Unlike some antibiotics such as rifampin, amoxicillin does not significantly affect the metabolism of hormonal contraceptives. Studies show that amoxicillin does not reduce estrogen or progestin levels enough to compromise contraceptive effectiveness. However, if you experience vomiting or severe diarrhea while taking amoxicillin, this could potentially reduce birth control absorption. The myth about antibiotics and birth control likely stems from early case reports and theoretical concerns that haven't been supported by clinical research. For peace of mind, consider using backup contraception if you're concerned about any potential interactions.

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