Can You Take Tylenol with Plan B?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Yes, Tylenol (acetaminophen) can be safely taken with Plan B emergency contraception. There are no known drug interactions between acetaminophen and levonorgestrel, the active ingredient in Plan B. Many women experience headaches, abdominal pain, or other discomfort after taking emergency contraception, and Tylenol can help manage these side effects. Clinical studies show that approximately 13-18% of Plan B users experience headaches within 24 hours of taking the medication. Taking 325-650mg of acetaminophen as needed is generally safe and effective for symptom relief. Always follow the dosing instructions on both medications and consult a pharmacist or healthcare provider if you have concerns about drug interactions.
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