Can You Take Tizanidine with Advil?

Yes, tizanidine and Advil (ibuprofen) can generally be taken together safely. These medications work through different mechanisms - tizanidine is a muscle relaxant that affects the central nervous system, while Advil is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain. No major direct interaction between tizanidine and ibuprofen is generally recognized, but that does not mean the combination is safe for everyone. Tizanidine can cause drowsiness, dizziness, and low blood pressure. Ibuprofen is not usually sedating, but seek medical advice if you feel unusually sleepy, dizzy, or faint after taking these medicines. Take tizanidine only at the dose and schedule prescribed for you. For adults using over-the-counter Advil, follow the package directions and do not exceed the labeled daily limit unless a healthcare professional tells you to. Check with a healthcare professional before combining them, especially if you have kidney, heart, liver, bleeding, or stomach-ulcer problems; are pregnant; or take blood thinners, blood-pressure medicines, sedatives, or other NSAIDs.