March 31, 2026 Pain & Musculoskeletal

Can You Take Flexeril and Tylenol Together?

Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 23rd, 2026.

Yes, Flexeril (cyclobenzaprine) and Tylenol (acetaminophen) can usually be taken together safely. These medications work through different mechanisms - Flexeril is a muscle relaxant that acts on the central nervous system, while Tylenol is a pain reliever that works peripherally. No significant drug interactions exist between these two medications according to major drug interaction databases. However, both can cause drowsiness, so the sedating effects may be enhanced when taken together. Most healthcare providers consider this combination appropriate for managing muscle pain and spasms. Always follow prescribed dosages and consult your doctor if you experience persistent side effects. If you're taking additional medications check with your healthcare provider or pharmacist for potential interactions. This includes over-the-counter drugs, as well as dietary or herbal supplements.