Can You Take Acetaminophen (Tylenol) with Muscle Relaxers?
Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 21st, 2026.
Yes, acetaminophen (Tylenol) is generally safe to take with most muscle relaxers like cyclobenzaprine, methocarbamol, and tizanidine. These medications work through different mechanisms and don't typically interact with each other. However, you should avoid exceeding 3,000-4,000mg of acetaminophen daily to prevent liver damage. Some combination medications already contain acetaminophen, so always check labels carefully. Always consult your healthcare provider or pharmacist before combining any medications, especially if you have liver conditions or take other prescription drugs. This includes over-the-counter drugs and dietary supplements.
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