Can Prednisone Cause High Blood Sugar?
Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.
Yes, prednisone commonly causes elevated blood sugar levels in both diabetic and non-diabetic patients. This corticosteroid increases glucose production in the liver while simultaneously reducing insulin sensitivity in muscle and fat tissues. Blood sugar can rise within hours of taking prednisone, but the amount and timing vary with the dose, dosing schedule, meals, and individual risk factors. The risk increases with higher doses and longer treatment duration. The risk of steroid-induced high blood sugar generally increases with higher prednisone doses, including doses of 20 mg daily or more, but individual risk varies. People with diabetes, prediabetes, or other risk factors may need blood glucose monitoring during prednisone therapy. Ask the prescribing clinician whether and how often to check.
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