Can Prednisone Cause High Blood Sugar?

Yes, prednisone commonly causes elevated blood sugar levels in both diabetic and non-diabetic patients. This corticosteroid increases glucose production in the liver while simultaneously reducing insulin sensitivity in muscle and fat tissues. Studies show that blood sugar levels can rise by 50-100 mg/dL within hours of taking prednisone, with peak effects occurring 4-8 hours after dosing. The risk increases with higher doses and longer treatment duration. Patients taking 20mg daily or more face significantly higher chances of developing steroid-induced diabetes. Blood glucose monitoring becomes essential during prednisone therapy, especially for those with pre-existing diabetes or prediabetes.

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