Symptoms & General Health

Can Low Calcium Cause Muscle Cramps?

Andre Stone | MD

Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.

Yes, low calcium levels can cause muscle cramps and spasms. Calcium plays a crucial role in muscle contraction and nerve function, so when blood calcium is too low, muscles may cramp or contract involuntarily. The cutoff varies by laboratory, and clinicians may need to account for albumin levels or measure ionized calcium.. This condition, called hypocalcemia, affects approximately 2-18% of hospitalized patients. Common symptoms include cramping in the hands, feet, and legs, along with tingling sensations around the mouth. The cramps may be accompanied by muscle twitching or sustained, painful muscle contractions called tetany. Causes of low calcium include vitamin D deficiency, parathyroid disorders, and certain medications, including some types of diuretics.

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