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Nexletol (bempedoic acid) is a prescription oral tablet approved to lower LDL cholesterol in adults. It is used as an add-on to diet and maximally tolerated statin therapy, and it is also an option for adults who are statin-intolerant and need LDL reduction to lower cardiovascular risk.

Nexletol inhibits ATP-citrate lyase, an enzyme in the liver that is part of the cholesterol biosynthesis pathway. By blocking this enzyme upstream of HMG-CoA reductase (the target of statins), it reduces the amount of LDL cholesterol the liver produces and releases into the bloodstream.

Nexletol is not appropriate for everyone. Patients with a history of gout should use it with caution because it can raise uric acid levels and trigger gout flares. It should not be used during pregnancy. Your physician will also review any current medications, including cyclosporine, simvastatin, and pravastatin, because Nexletol can increase blood levels of certain drugs.

The most commonly reported side effects include upper respiratory infections, muscle spasm, hyperuricemia (elevated uric acid), back pain, abdominal pain or discomfort, bronchitis, and anemia. Tendon rupture has been reported rarely. Contact your doctor if you experience sudden joint or tendon pain.

In clinical trials, meaningful LDL reductions were observed within 4 to 8 weeks of starting Nexletol. Your physician will typically check a lipid panel after about 8 to 12 weeks to assess your response and adjust your overall treatment plan if needed.

Yes. Nexletol is specifically approved for adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who cannot tolerate statins at recommended doses. Because it works through a different mechanism than statins, many patients who experience statin-related muscle symptoms tolerate Nexletol well, though individual responses vary.

Doctronic uses an AI-powered evaluation to gather your symptoms, medical history, and current medications. A licensed physician then reviews your information, makes a clinical determination, and if appropriate, creates a personalized treatment plan including a prescription. The entire process is completed online.

Yes. Doctronic connects you with fully licensed physicians who are board-eligible or board-certified in their specialties. All consultations are doctor-reviewed, regularly audited for clinical quality, and conducted on a HIPAA-compliant platform to protect your health information.