Contents
What Triggers Zollinger-Ellison Syndrome? Discover the Hidden Causes!
Published: Jan 07, 2024
Zollinger-Ellison Syndrome is a condition driven by gastrin-secreting tumors. Learn about the underlying causes and how they impact your health.
The Role of Gastrinomas
Gastrinomas are tumors that secrete large amounts of gastrin, leading to excessive stomach acid production. These tumors are most commonly found in the pancreas or duodenum, but they can also occur in other parts of the body. Gastrinomas are the primary cause of Zollinger-Ellison Syndrome.
Genetic Links to MEN1
A significant number of ZES cases are associated with Multiple Endocrine Neoplasia Type 1 (MEN1), a genetic condition that causes multiple tumors. Patients with MEN1 have a higher risk of developing gastrinomas, highlighting the importance of genetic screening for at-risk individuals.
Sporadic Cases
While many cases are linked to genetics, the majority of gastrinomas are sporadic, meaning they occur without a family history. These cases still cause the same symptoms and require similar diagnostic and treatment approaches.
Frequently Asked Questions
It's caused by gastrin-secreting tumors known as gastrinomas.
Yes, 20-30% of cases are linked to MEN1, a genetic disorder.
Commonly in the pancreas or duodenum.
Yes, most cases are sporadic without a genetic link.
The Bottom Line
Understanding the causes of ZES can help in early detection and management of the condition.
References
- Kulke MH, Anthony LB, Bushnell DL, et al. NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas 2010; 39:735.
- Metz DC, Jensen RT. Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. Gastroenterology 2008; 135:1469.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
AI Doctor Visit Required
Appointments available 24/7
Top licensed doctors
Available in all 50 states
Full service care
Prescriptions, referrals & treatment
No insurance needed
All notes available in Doctronic
15-min consultation. No hidden costs.
AI Doctor Visit Required
Please Chat With Our AI Doctor First
Our AI doctor assessment helps our human doctors prepare for your video visit and provide better care
For safety reasons we have been forced to end this consultation.
If you believe this is a medical emergency please call 911 or your local emergency services immediately.
If you are experiencing emotional distress, please call the the Suicide & Crisis Lifeline at 988 or your local crisis services immediately.
Contact us
You can also email us at help@doctronic.ai
We aim to reply within 5-7 days
How likely are you to recommend Doctronic to friends or family?