Contents
What Is Zollinger-Ellison Syndrome? Uncover the Mysteries Behind This Rare Condition!
Published: Oct 01, 2024
Zollinger-Ellison Syndrome is a rare condition causing excessive stomach acid production, leading to severe ulcers and diarrhea. Understanding its causes and symptoms can help in early diagnosis and treatment.
What Causes Zollinger-Ellison Syndrome?
Zollinger-Ellison Syndrome (ZES) is caused by tumors called gastrinomas, which secrete excess gastrin, a hormone that triggers stomach acid production. These tumors are often found in the pancreas or duodenum and can lead to severe peptic ulcers. Interestingly, about 20-30% of these cases are linked to a genetic disorder called Multiple Endocrine Neoplasia Type 1 (MEN1).
Recognizing the Symptoms
Common symptoms of ZES include severe stomach ulcers, persistent heartburn, and chronic diarrhea. These symptoms result from excessive stomach acid that damages the digestive tract. Some patients also experience weight loss and gastrointestinal bleeding, making early recognition crucial for effective management.
Diagnosing the Condition
Diagnosis of ZES involves detecting high levels of gastrin in the blood, especially when the stomach's pH is low. Tests like the secretin stimulation test can help differentiate ZES from other conditions. Imaging studies may also be used to locate gastrinomas and assess the extent of the disease.
Frequently Asked Questions
It's a condition where tumors cause excessive stomach acid production.
Severe ulcers, heartburn, and diarrhea are common symptoms.
By measuring high gastrin levels and using imaging tests.
Yes, about 20-30% of cases are linked to MEN1.
Key Takeaways
Understanding the causes and symptoms of ZES is vital for early diagnosis and treatment.
References
- ZOLLINGER RM, ELLISON EH. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 1955; 142:709.
- Ellison EC, Johnson JA. The Zollinger-Ellison syndrome: a comprehensive review of historical, scientific, and clinical considerations. Curr Probl Surg 2009; 46:13.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
AI Doctor Visit Required
Appointments available 24/7
Top licensed doctors
Available in all 50 states
Full service care
Prescriptions, referrals & treatment
No insurance needed
All notes available in Doctronic
15-min consultation. No hidden costs.
AI Doctor Visit Required
Please Chat With Our AI Doctor First
Our AI doctor assessment helps our human doctors prepare for your video visit and provide better care
For safety reasons we have been forced to end this consultation.
If you believe this is a medical emergency please call 911 or your local emergency services immediately.
If you are experiencing emotional distress, please call the the Suicide & Crisis Lifeline at 988 or your local crisis services immediately.
Contact us
You can also email us at help@doctronic.ai
We aim to reply within 5-7 days
How likely are you to recommend Doctronic to friends or family?