What is G6PD Deficiency and How Does It Affect You?

What is G6PD Deficiency?

G6PD deficiency is an inherited disorder caused by a defect in the enzyme glucose-6-phosphate dehydrogenase (G6PD) in red blood cells. This enzyme is crucial for protecting cells from oxidative damage. Without enough G6PD, red blood cells are more likely to break down under oxidative stress, leading to a condition known as hemolytic anemia. G6PD deficiency is the most common enzyme disorder of red blood cells, affecting millions worldwide.

Who is Affected?

G6PD deficiency has a widespread global presence, particularly in regions like Africa, the Middle East, and Asia, where malaria is or was common. It is an X-linked disorder, primarily affecting males, although females can be carriers. In specific populations, such as Kurdish Jews, the prevalence can be as high as 60 to 70 percent. The disorder's geographical distribution suggests a historical advantage against malaria, similar to other red blood cell disorders.

Symptoms and Triggers

Symptoms of G6PD deficiency can range from mild to severe and often depend on the level of oxidative stress. Triggers include certain foods like fava beans, medications such as primaquine, and infections. Symptoms can include jaundice, dark urine, fatigue, and shortness of breath. In severe cases, individuals may experience acute hemolytic anemia, requiring medical attention.

Frequently Asked Questions

Key Takeaways

Understanding and managing G6PD deficiency is crucial for preventing complications.

Related Articles

• Are These Medications Safe for You? A Guide for G6PD Deficient Individuals
• The Foods You Should Avoid If You Have G6PD Deficiency
• How is G6PD Deficiency Diagnosed? Tests You Should Know About
• Managing G6PD Deficiency: What You Need to Know

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