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What Causes Angioedema? Discover the Surprising Triggers!
Published: Sep 14, 2023
Angioedema is a sudden swelling of the skin and tissues beneath it. Let's dive into what causes this mysterious condition.
Mast Cell-Mediated Angioedema
Mast cells release substances like histamine, causing blood vessels to leak fluid into surrounding tissues. This type of angioedema often comes with hives and itching. Common triggers include allergens like foods and medications. Treatment usually involves antihistamines and, in severe cases, epinephrine.
Bradykinin-Mediated Angioedema
This type occurs when the body has too much bradykinin, leading to swelling without itching or hives. It's often triggered by medications like ACE inhibitors. Unlike mast cell-mediated angioedema, it doesn't respond to antihistamines, requiring specific treatments targeting bradykinin.
Unknown Mechanisms
Some angioedema cases remain a mystery in terms of causes. Idiopathic angioedema occurs without known triggers and can be challenging to manage. In children, infections are a common association, while adults may experience it without any clear reason.
Frequently Asked Questions
It's swelling of skin and tissues beneath, often sudden.
Allergens like foods and medications are common triggers.
It requires treatment targeting bradykinin, not antihistamines.
The exact cause is unknown, making it hard to manage.
The Mystery Continues
Angioedema remains a complex condition with varied causes and treatments.
References
- Lin RY, Cannon AG, Teitel AD. Pattern of hospitalizations for angioedema in New York. Ann Allergy Asthma Immunol 2005; 95:159.
- Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis after red meat consumption. J Allergy Clin Immunol 2009; 123:426.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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