Uncovering the Hidden Causes of Hypercalcemia

Published: Mar 29, 2024

While common causes of hypercalcemia are well-known, some lesser-known conditions can also lead to elevated calcium levels. This article delves into these hidden causes.

Familial Hypocalciuric Hypercalcemia

Familial hypocalciuric hypercalcemia is a rare genetic condition where the body absorbs too much calcium from food. Unlike other types of hypercalcemia, this condition is often asymptomatic and discovered through routine blood tests. It is important to differentiate this from other causes to avoid unnecessary treatment.

Vitamin D Intoxication

Excessive intake of vitamin D can cause hypercalcemia by increasing calcium absorption from the gut. This condition is often a result of taking high doses of vitamin D supplements without medical supervision. Recognizing this cause is vital to prevent potential complications from prolonged high calcium levels.

Hypercalcemia is a condition characterized by elevated levels of calcium in the blood. While common causes are well-known, it can also be caused by rare conditions such as familial hypocalciuric hypercalcemia and excessive vitamin D intake.

Granulomatous Diseases

Certain diseases, like sarcoidosis, can lead to hypercalcemia by increasing the production of vitamin D. These conditions stimulate the immune system to produce more vitamin D, leading to higher calcium levels. Identifying these diseases is crucial for effective management of hypercalcemia.

Frequently Asked Questions

What is familial hypocalciuric hypercalcemia? +

It's a genetic condition causing excessive calcium absorption.

Can too much vitamin D cause hypercalcemia? +

Yes, excessive vitamin D intake increases calcium absorption.

How do granulomatous diseases affect calcium levels? +

They increase vitamin D production, raising calcium levels.

Key Takeaways

Understanding these hidden causes is essential for accurate diagnosis and treatment.

Discover more about these hidden causes by chatting with Doctronic.

References

Ratcliffe WA, Hutchesson AC, Bundred NJ, Ratcliffe JG. Role of assays for parathyroid-hormone-related protein in investigation of hypercalcaemia. Lancet 1992; 339:164.

Schilling T, Pecherstorfer M, Blind E, et al. Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy. J Clin Endocrinol Metab 1993; 76:801.

Always discuss health information with your healthcare provider.