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How Is Waldenström Macroglobulinemia Diagnosed?
Published: Feb 10, 2024
Diagnosing Waldenström macroglobulinemia (WM) involves a series of tests and evaluations to confirm this complex condition.
Blood Tests
A key part of diagnosing WM is measuring IgM protein levels in the blood. High levels of this protein suggest the presence of WM. Tests like serum protein electrophoresis and immunofixation help identify and confirm these levels.
Bone Marrow Biopsy
A bone marrow biopsy is crucial for diagnosing WM. This test checks for cancerous cells that infiltrate the bone marrow, which is typical in WM. The biopsy also helps distinguish WM from other similar conditions.
Genetic Testing
Genetic tests can detect MYD88 mutations, which are common in WM patients. These tests aid in differentiating WM from other blood disorders, ensuring an accurate diagnosis.
Frequently Asked Questions
Blood tests and bone marrow biopsies are key to diagnosing WM.
It confirms cancerous cell infiltration typical in WM.
Yes, they identify MYD88 mutations common in WM.
High IgM levels suggest WM presence.
Diagnosis Insights
Accurate diagnosis of WM requires multiple tests to confirm the condition.
References
- World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Swerdlow SH, Campo E, Harris NL, et al. (Eds), IARC Press, Lyon 2008.
- Owen RG, Treon SP, Al-Katib A, et al. Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol 2003; 30:110.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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