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How Do Doctors Diagnose Paget Disease of the Breast?
Published: Oct 01, 2023
Early and accurate diagnosis of Paget disease can be crucial for effective treatment. Let's dive into the tests involved.
Skin Biopsy: The Gold Standard
When Paget disease is suspected, a skin biopsy of the nipple is typically performed. This involves taking a small sample of skin to look for Paget cells under a microscope. The presence of these cells confirms the diagnosis, distinguishing it from other skin conditions.
Imaging: Seeing Beneath the Surface
Mammography and ultrasound are used to detect any underlying breast cancer. These imaging techniques help identify masses or abnormalities that may not be visible externally. In some cases, an MRI might be used for a clearer picture, especially if the mammogram is negative.
What to Expect During the Evaluation
Patients will undergo a thorough physical exam and detailed personal and family medical history check. Doctors may also conduct hormone receptor and HER2 status tests on any underlying cancer. These tests help guide treatment decisions.
Frequently Asked Questions
A skin biopsy looking for Paget cells.
Mammography, ultrasound, and sometimes MRI.
It identifies underlying breast cancer.
Physical exams and family medical history.
The Bottom Line
Accurate diagnosis of Paget disease involves multiple tests to ensure effective treatment.
References
- Adams SJ, Kanthan R. Paget's disease of the male breast in the 21st century: A systematic review. Breast 2016; 29:14.
- Zakaria S, Pantvaidya G, Ghosh K, Degnim AC. Paget's disease of the breast: accuracy of preoperative assessment. Breast Cancer Res Treat 2007; 102:137.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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