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Exploring Treatment Options for Zollinger-Ellison Syndrome
Published: Apr 26, 2024
Zollinger-Ellison syndrome (ZES) requires a comprehensive treatment approach. Let's delve into the options available for managing this condition.
Medical Management
Medications play a crucial role in managing ZES. Proton pump inhibitors (PPIs) are often prescribed to reduce stomach acid production. In some cases, somatostatin analogs like octreotide may be used to control gastrin secretion.
Surgical Interventions
Surgery may be an option for patients with localized gastrinomas. The goal is to remove the tumors and reduce the need for ongoing medication. Surgical intervention can offer a chance for cure in select patients.
Managing Metastatic Disease
For patients with metastatic ZES, treatment options include liver-directed therapies and chemotherapy. These approaches aim to control tumor growth and manage symptoms. The choice of treatment depends on the extent and location of metastases.
Frequently Asked Questions
PPIs are the mainstay to control stomach acid in ZES.
Surgery can cure localized gastrinomas but not metastatic disease.
Metastatic ZES may require liver-directed therapies or chemotherapy.
Somatostatin analogs may be used for hormone control in ZES.
Wrapping Up
ZES treatment requires a personalized approach based on disease stage and patient needs.
References
- Rossi RE, Elvevi A, Citterio D, et al. Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies. World J Gastroenterol 2021; 27:5890.
- Norton JA, Fraker DL, Alexander HR, et al. Surgery increases survival in patients with gastrinoma. Ann Surg 2006; 244:410.
- Metz DC, Pisegna JR, Fishbeyn VA, et al. Control of gastric acid hypersecretion in the management of patients with Zollinger-Ellison syndrome. World J Surg 1993; 17:468.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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