Effective Treatments for Postherpetic Neuralgia: What Works?
Published: Jun 14, 2024
For those suffering from postherpetic neuralgia (PHN), finding relief is crucial. This article explores the various treatments available to manage PHN effectively.
Contents
Initial Treatment Options
Gabapentinoids like gabapentin and pregabalin are often the first line of treatment for PHN. These medications help manage pain by altering nerve signals, and are generally well-tolerated. For those who prefer non-pill options, topical treatments such as capsaicin cream are viable alternatives.
Alternative Therapies
When initial treatments are ineffective, alternative medications like tricyclic antidepressants and serotonin-norepinephrine reuptake inhibitors can be considered. These drugs help by affecting the brain chemicals that influence pain perception, offering another layer of pain management.

Adjunctive and Advanced Options
In severe cases, patients may benefit from opioid analgesics or intrathecal glucocorticoid injections. These treatments are typically reserved for those who have not responded to other therapies and are used under careful medical supervision.
Frequently Asked Questions
Gabapentinoids and capsaicin creams are commonly used first.
Tricyclic antidepressants and SNRIs are alternative options.
Yes, but they are reserved for severe cases and used cautiously.
While challenging, multimodal therapy can significantly reduce pain.
The Bottom Line
Could a tailored treatment plan be your path to relief?
References
- Moore RA, Wiffen PJ, Derry S, McQuay HJ. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev 2011; :CD007938.
- Derry S, Bell RF, Straube S, et al. Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev 2019; 1:CD007076.
- Harden RN, Kaye AD, Kintanar T, Argoff CE. Evidence-based guidance for the management of postherpetic neuralgia in primary care. Postgrad Med 2013; 125:191.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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