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Could Your Medications Be Causing Hypercalcemia?
Published: Jul 24, 2024
Medications can sometimes lead to unexpected side effects, including hypercalcemia. Let's explore which ones.
Lithium's Role
Lithium, used for mood stabilization, can cause mild hypercalcemia by increasing parathyroid hormone release. This happens because lithium alters the calcium set point, leading to higher blood calcium levels. Monitoring calcium levels is crucial for patients on long-term lithium therapy to prevent complications.
Thiazide Diuretics
Thiazide diuretics, prescribed for high blood pressure, reduce calcium excretion, potentially leading to hypercalcemia. While beneficial for preventing kidney stones, they can increase calcium levels in people with underlying hyperparathyroidism. Regularly checking calcium levels can help manage this side effect.
PTH and PTHrP Analogs
Osteoporosis treatments using PTH and PTHrP analogs can temporarily raise calcium levels. These drugs increase bone formation but also bone resorption, leading to elevated blood calcium. Patients on these medications should have their calcium levels monitored to avoid hypercalcemia.
Frequently Asked Questions
Yes, lithium can lead to mild hypercalcemia.
Thiazides reduce calcium excretion, potentially causing hypercalcemia.
Yes, PTH and PTHrP analogs can raise calcium levels.
Patients on lithium or thiazides should check calcium levels.
The Bottom Line
Understanding your medications' side effects can help prevent hypercalcemia.
References
- Walker MD, Shane E. Hypercalcemia: A Review. JAMA 2022; 328:1624.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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