Contents
How Do Treatments for Hypercalcemia Work?
Published: Sep 19, 2024
Hypercalcemia treatments vary based on the cause. Let's delve into the options.
Hydration and Diuretics
The first line of treatment often involves hydration with intravenous saline to help excrete excess calcium. Diuretics may also be used to increase urine output and further lower calcium levels. This approach is effective in acute cases and helps prevent complications.
Bisphosphonates
Bisphosphonates are used to treat hypercalcemia caused by excessive bone resorption. They work by inhibiting bone breakdown, thus lowering calcium levels in the blood. This treatment is particularly useful for hypercalcemia associated with cancers affecting the bone.
Glucocorticoids
In cases of vitamin D-related hypercalcemia, glucocorticoids can help reduce calcium absorption and resorption. They are effective in conditions like sarcoidosis or vitamin D intoxication. Patients should be monitored closely due to potential side effects of long-term steroid use.
Frequently Asked Questions
Hydration with saline is commonly used first.
They reduce bone resorption, lowering calcium levels.
They're used for vitamin D-related hypercalcemia.
Yes, treatments can have side effects and need monitoring.
Wrapping Up
Effective treatment of hypercalcemia relies on understanding its underlying cause.
References
- Walker MD, Shane E. Hypercalcemia: A Review. JAMA 2022; 328:1624.
- Selby PL, Davies M, Marks JS, Mawer EB. Vitamin D intoxication causes hypercalcaemia by increased bone resorption which responds to pamidronate. Clin Endocrinol (Oxf) 1995; 43:531.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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