Could Dementia with Lewy Bodies Be the Most Misunderstood Condition?
Published: Mar 24, 2024
Dementia with Lewy bodies (DLB) is often overshadowed by Alzheimer's, yet it has unique symptoms and challenges. Understanding its prognosis and treatment is crucial for patients and caregivers.
Contents
Shorter Life Expectancy
DLB patients typically live between 1.8 to 9.5 years after diagnosis, with an average of about 6.1 years. This is somewhat shorter than those with Alzheimer's but similar to Parkinson's disease dementia (PDD). Factors like cognitive fluctuations and parkinsonism can influence prognosis.
Cognitive Decline and Challenges
Cognitive decline in DLB is progressive, with patients transitioning to severe dementia faster than Alzheimer's. Biomarkers indicating Alzheimer's pathology can worsen the decline. Early hallucinations and gait issues are also common challenges.
Parkinsonism and Nonmotor Symptoms
Most DLB patients exhibit parkinsonism, worsening over time. Nonmotor symptoms such as autonomic dysfunction lead to complications like urinary infections. Behavioral symptoms including hallucinations can increase caregiver burden.
Frequently Asked Questions
The average life expectancy is about 6.1 years.
Yes, cognitive decline in DLB is typically faster.
Autonomic dysfunction and behavioral symptoms are common.
Yes, due to severe symptoms and caregiver strain.
Key Takeaways
DLB presents unique challenges and understanding its progression is vital.
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References
Cercy SP, Bylsma FW. Lewy bodies and progressive dementia: a critical review and meta-analysis. J Int Neuropsychol Soc 1997; 3:179.
Williams MM, Xiong C, Morris JC, Galvin JE. Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology 2006; 67:1935.
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