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Can These Therapies Ease Dementia with Lewy Bodies Symptoms?
Published: Jun 03, 2024
Treating DLB involves a careful balance of medications and therapies to manage symptoms and improve quality of life. Here's what you need to know.
Cholinesterase Inhibitors: A First-Line Defense
Cholinesterase inhibitors like donepezil and rivastigmine are often used to treat cognitive and behavioral symptoms in DLB. They help improve cognition but can have side effects such as weight loss. It's important to monitor patients carefully.
Memantine: A Second-Line Option
Memantine may be used if cholinesterase inhibitors are not tolerated, though evidence in DLB is limited. It can help with cognitive symptoms but may worsen hallucinations. Caution is advised, particularly in patients with renal issues.
Nonpharmacologic Strategies
Non-drug approaches like modifying environmental stressors can be effective. These strategies aim to manage symptoms without the adverse effects of medication. They are vital in a comprehensive care plan for DLB.
Antipsychotic Use in DLB
Antipsychotics are reserved for severe symptoms due to potential severe side effects. Atypical antipsychotics in low doses are preferred, with a focus on minimizing risks.
Frequently Asked Questions
Cholinesterase inhibitors are widely used.
Memantine is sometimes used but evidence is limited.
Yes, they help manage symptoms without side effects.
They can cause severe side effects in DLB patients.
Weight loss is a recognized side effect.
The Bottom Line
Managing DLB symptoms requires a personalized approach and careful monitoring.
References
- Stinton C, McKeith I, Taylor JP, et al. Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. Am J Psychiatry 2015; 172:731.
- Simard M, van Reekum R. The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies. J Neuropsychiatry Clin Neurosci 2004; 16:409.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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