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Combination Therapy for Crohn's Disease: When Two Treatments Are Better Than One
Published: Dec 17, 2023
In the battle against Crohn's disease, sometimes one treatment isn't enough. That's where combination therapy comes in. This approach pairs different medications to pack a more powerful punch against inflammation and symptoms.
What is Combination Therapy?
Combination therapy for Crohn's disease typically involves using a biologic drug along with an immunomodulator. Biologics, like infliximab or adalimumab, target specific parts of the immune system to reduce inflammation. Immunomodulators, such as azathioprine or methotrexate, work more broadly to suppress the immune response. Together, they can be more effective than either medication alone.
Benefits of the Tag-Team Approach
Research has shown that combination therapy can be more effective at inducing and maintaining remission in Crohn's disease compared to single-drug treatments. It may lead to faster symptom relief and better healing of the intestinal lining. Additionally, using an immunomodulator alongside a biologic can help prevent the body from developing antibodies against the biologic, allowing it to work better for longer.
Potential Risks and Side Effects
While combination therapy can be very effective, it does come with some additional risks. Using two immunosuppressive medications can increase the chance of infections. There's also a small increased risk of certain cancers, particularly lymphoma, especially in younger male patients. However, for many patients, the benefits of better disease control outweigh these risks.
Is Combination Therapy Right for You?
The decision to use combination therapy depends on several factors, including the severity of your Crohn's disease, your overall health, and your response to previous treatments. It's often recommended for patients with more severe disease or those who haven't responded well to other treatments. Your doctor will carefully weigh the potential benefits and risks for your individual situation.
Frequently Asked Questions
It varies, but often for at least a year.
Never stop without consulting your doctor first.
Yes, your doctor can discuss other options.
Often yes, but check with your provider.
Yes, but medication adjustments may be necessary.
A Tailored Approach
Combination therapy offers a powerful tool in managing Crohn's disease, but it's not one-size-fits-all.
References
- Colombel JF, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med. 2010;362(15):1383-1395.
- Lichtenstein GR, et al. ACG Clinical Guideline: Management of Crohn's Disease in Adults. Am J Gastroenterol. 2018;113(4):481-517.
- Feuerstein JD, et al. AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease. Gastroenterology. 2021;160(7):2496-2508.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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